ABSENCE OF OXIDATIVE STRESS AND SIRTUINS RECRUITMENT ON CARDIAC TISSUE POST STRESS

Stress has emerged as a factor associated with cardiovascular disease. Catecholamines released during the stress reaction by sympathetic nerves and adrenal medulla couple to β1-and β2-adrenoceptors in cardiomyocytes membrane enhancing heart function order attend organism demand. This might produce excessive reactive oxygen species what may culminate oxidative progression of several cardiac diseases. Sirtuins have been described cardioprotective factors important regulators cellular response heart. The aim this work is investigate putative participation sirtuins rats submitted foot shock stress, an experimental model where there up regulation downregulation β1-adrenoceptors. data shown that myocardium H2O2 concentration, catalase superoxide dismutase activity, NAD+/NADH ratio, well protein expression 1 3 were not altered. Pharmacological blockade ICI118,551, did modify scenario. It concluded does cause disruptions or redox state processes myocardium, consequently, are recruited response.